Aging and Age-Related Disorders by Stephen Bondy & Kenneth Maiese

Author:Stephen Bondy & Kenneth Maiese
Language: eng
Format: epub
Publisher: Humana Press, Totowa, NJ

10 Conclusions

There is extensive evidence that implicates free radicals in atherosclerosis and other vascular diseases. Plaques that demonstrate oxidative damage and its effects including cellular senescence and apoptosis in multiple cell types support this notion. Senescence and apoptosis in advanced atherosclerotic plaques are deleterious and may promote plaque rupture. In contrast, clinical trials have shown that there is, at present, no strong consensus on the beneficial effects of antioxidant supplements in cardiovascular disease, and that strategies that reduce free radicals indirectly, for example by lowering cholesterol levels, are more successful. In contrast, recent experiments showing the protective effects of antioxidant enzymes in animal models strongly support the role of intracellular antioxidant systems in protecting against vascular disease. The study of intracellular pathways that counteract the effects of oxidative stress may prove beneficial in the future.

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